BioMS Centre:
Country: Italy
City: Pavia
Institution: IRCCS Mondino Foundation
PI/Co-PI: Matteo Gastaldi
Team members (name, position and contact e-mail):
Elisabetta Zardini, Co-Head of the diagnostic Neuroimmunology Lab (elisabetta.zardini@mondino.it)
Silvia Scaranzin, Neurobiologist (silvia.scaranzin@mondino.it)
Chiara Morandi, Neurobiologist (chiara.morandi@mondino.it)
Stefano Masciocchi, Neurologist, PhD Student (stefano.masciocchi@mondino.it)
Biomarker research interest:
Our group is dedicated to the study of antibody-mediated disorders of the central and peryhperal nervous system, with a specific interest for conformational antibodies. Our main research lines inlcude:
- Standardization of laboratory assays for the detection of neuroglial antibodies
- Investigation of neuronal antibody-associated disorders, with a specific focus on autoimmune encephalitis, and the relevance of wide neuronal antibody screening in patients with psychotic disorders
- Investigation of prognostic biomarkers in MOG and AQP4 mediated disorders
- Investigation of patient-derived MOG-IgG monoclonal antibodies on animal models
- Identification of conformational neuroglial antibodies in MS patients and in other demyelinating disorders
- Investigation of the relevance of paranodal antibodies in inflammatory neurpathies