BioMS Centre:

Neuroimmunology and CSF Neurochemistry Unit, Institute of Neuroscience

Country: Belgium

City: Brussels

Institution: UCLouvain



PI/Co-PI:  Prof. Vincent van Pesch,

Team members (name, position and contact e-mail):

Dr. Océane Perdaens, PhD,

Dr. Matthieu Deltombe, PhD,

Hong Anh Dang, technician,

Our group is committed to characterize the immune response and the cytokine network at play primarily in Multiple Sclerosis (MS) but also in other neurological disorders. We manage an expanding biobank of peripheral blood mononuclear cells (PBMC) from MS patients as well as cerebrospinal fluid (CSF) and serum from patients of the Neurology Department at the Cliniques Universitaires Saint-Luc. We have characterized the Th17/Treg balance and the involvement of their cytokines during MS relapses and remission or following MS treatments. Recently, the group has broadened its investigation of MS pathogenesis by studying microRNAs (miRNA), bioactive lipids and their putative carriers (extracellular vesicles: EVs) for their roles in MS neuroinflammation as well as on the development of oligodendrocytes.